Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer

MengFang Xia; YaZhuo Zhang; Ke Jin; ZiTong Lu; Zhaoyang Zeng; Wei Xiong

doi:10.1186/s13578-019-0289-8

Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer

Cell Biosci. 2019 Mar 19:9:27. doi: 10.1186/s13578-019-0289-8. eCollection 2019.

Authors

MengFang Xia^#^{1

2

3}, YaZhuo Zhang^#^{1

2

3}, Ke Jin², ZiTong Lu², Zhaoyang Zeng^{1

2

3}, Wei Xiong^{1

2

3}

Affiliations

¹ 1NHC Key Laboratory of Carcinogenesis, Xiangya Hospital, Central South University, Changsha, Hunan China.
² 2The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan China.
³ 3Hunan Key Laboratory of Non Resolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan China.

^# Contributed equally.

Abstract

Mitochondria are energy factories of cells and are important pivots for intracellular interactions with other organelles. They interact with the endoplasmic reticulum, peroxisomes, and nucleus through signal transduction, vesicle transport, and membrane contact sites to regulate energy metabolism, biosynthesis, immune response, and cell turnover. However, when the communication between organelles fails and the mitochondria are dysfunctional, it may induce tumorigenesis. In this review, we elaborate on how mitochondria interact with the endoplasmic reticulum, peroxisomes, and cell nuclei, as well as the relation between organelle communication and tumor development .

Keywords: Carcinogenesis; Cell nucleus; Endoplasmic reticulum; Mitochondria; Organelle communication; Peroxisomes.

Publication types

Review