The claustrum is a target for projections from the supramammillary nucleus in the rat

Neuroscience. 2019 Jun 15:409:261-275. doi: 10.1016/j.neuroscience.2019.03.045. Epub 2019 Mar 28.

Abstract

Injection of the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHAL) into the rat rostral and caudal supramammillary nucleus (SUM) provided expected patterns of projections into the hippocampus and the septal region. In addition, unexpectedly intense projections were observed into the claustrum defined by parvalbumin expression. Injections of the retrograde tracer fluorogold (FG) into the hippocampus and the region of the claustrum showed that the cells of origin of these projections distributed similarly within the borders of the SUM. The SUM is usually involved in control of hippocampal theta activity, but the observation of intense projections into the claustrum indicates that it may also influence isocortical processes. Therefore, the SUM may coordinate sensory processing in the isocortex with memory formation in the hippocampus.

Keywords: dentate gyrus; parvalbumin; salience; septum; tract tracing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Claustrum / drug effects
  • Claustrum / physiology*
  • Hypothalamus, Posterior / drug effects
  • Hypothalamus, Posterior / physiology*
  • Neural Pathways / drug effects
  • Neural Pathways / physiology
  • Neuroanatomical Tract-Tracing Techniques
  • Neuronal Tract-Tracers / pharmacology
  • Neurons / drug effects
  • Neurons / physiology*
  • Rats

Substances

  • Neuronal Tract-Tracers