The recent developments in asymmetric A³ (aldehyde⁻alkyne⁻amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks.
Keywords: aldehydes; alkynes; amines; asymmetric catalysis; copper; multicomponent reactions; nitrogen heterocycles.