Plasma histamine elevation in a large cohort of sickle cell disease patients

Slimane Allali; François Lionnet; Sarah Mattioni; Jacques Callebert; Katia Stankovic Stojanovic; Claude Bachmeyer; Jean-Benoit Arlet; Valentine Brousse; Mariane de Montalembert; Martin Chalumeau; Gilles Grateau; Thiago T Maciel; Jean-Marie Launay; Olivier Hermine; Sophie Georgin-Lavialle

doi:10.1111/bjh.15900

Plasma histamine elevation in a large cohort of sickle cell disease patients

Br J Haematol. 2019 Jul;186(1):125-129. doi: 10.1111/bjh.15900. Epub 2019 Mar 28.

Authors

Slimane Allali^{1

2

3}, François Lionnet⁴, Sarah Mattioni⁴, Jacques Callebert⁵, Katia Stankovic Stojanovic⁴, Claude Bachmeyer⁴, Jean-Benoit Arlet^{2

3

6}, Valentine Brousse^{1

3}, Mariane de Montalembert^{1

3}, Martin Chalumeau^{1

3

7}, Gilles Grateau⁴, Thiago T Maciel^{2

3}, Jean-Marie Launay^{3

5}, Olivier Hermine^{2

3

8

9}, Sophie Georgin-Lavialle⁴

Affiliations

¹ Department of General Paediatrics and Paediatric Infectious Diseases, Necker Hospital for Sick Children, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris Descartes University, Paris, France.
² Laboratory of Cellular and Molecular Mechanisms of Haematological Disorders and Therapeutical Implications, Paris Descartes - Sorbonne Paris Cite ́ University, Imagine Institute, Inserm U1163, Paris, France.
³ Laboratory of Excellence GR-Ex, Paris, France.
⁴ Department of Internal Medicine, Tenon Hospital, AP-HP, Paris VI University, Paris, France.
⁵ Department of Biochemistry and Molecular Biology, Inserm UMR942, Lariboisière Hospital, AP-HP, Paris Descartes University, Paris, France.
⁶ Department of Internal Medicine, Georges-Pompidou European Hospital, AP-HP, Paris Descartes University, Paris, France.
⁷ Obstetrical, Perinatal and Paediatric Epidemiology Research Team (EPOPé), Inserm UMR1153, Paris, France.
⁸ Department of Haematology, Necker Hospital for Sick Children, AP-HP, Paris Descartes University, Paris, France.
⁹ Reference Center for Mastocytosis, Necker Hospital for Sick Children, AP-HP, Paris, France.

PMID: 30924132
DOI: 10.1111/bjh.15900

Abstract

The role of mast cells has been questioned in sickle cell disease (SCD). We performed a prospective study evaluating plasma histamine and tryptase levels in a cohort of paediatric and adult patients, in steady state (n = 132) and during vaso-occlusive crisis (VOC) (n = 121). Histamine level was elevated in 18% of patients in steady state and in 61% during VOC. Median histamine level was significantly higher during VOC than in steady state (24·1 [7·0-45·0] vs 9·6 [6·2-14·4] nmol/l, P < 0·0001). Tryptase level was slightly increased during VOC without reaching pathological values. These results suggest a role of mast cell activation in SCD pathophysiology.

Keywords: histamine; mast cell activation; sickle cell disease; tryptase; vaso-occlusive crisis.

MeSH terms

Adult
Anemia, Sickle Cell / blood*
Anemia, Sickle Cell / complications
Anemia, Sickle Cell / pathology
Child
Cohort Studies
Female
Histamine / blood*
Humans
Male
Mast Cells / metabolism
Prospective Studies
Tryptases / blood
Vascular Diseases / blood
Vascular Diseases / etiology

Substances

Histamine
Tryptases