A lung cancer patient with deep vein thrombosis:a case report and literature review

BMC Cancer. 2019 Mar 29;19(1):285. doi: 10.1186/s12885-019-5513-8.

Abstract

Background: Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing, especially for patients with lung cancer. Common features of these patients, like advanced stage, male gender, old age and chemotherapy, are risk factors of VTE. Here we reported a case in which the patient with lung cancer developed deep vein thrombosis (DVT) when receiving chemotherapy.

Case presentation: A 53-year-old male who was diagnosed with lung cancer with multiple metastasis developed severe DVT during chemotherapy. Despite the use of aspirin, warfarin and low molecular weight heparin (LMWH) for anticoagulant and thrombolytic therapy, the condition was still deteriorating, resulting in amputation finally.

Conclusions: It's rare that the conditions of cancer patients who develop venous thromboembolism (VTE) keep deteriorating despite the administration of aspirin, warfarin and low weight molecular heparin. Both early diagnosis and prophylactic use of anticoagulants are suggested for cancer patients to improve the prognosis.

Keywords: Case report; Chemotherapy; Deep venous thrombosis; Lung cancer.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amputation, Surgical
  • Anticoagulants / administration & dosage
  • Anticoagulants / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Humans
  • Lung Neoplasms / drug therapy*
  • Male
  • Middle Aged
  • Paclitaxel / administration & dosage
  • Paclitaxel / adverse effects
  • Treatment Failure
  • Venous Thrombosis / chemically induced
  • Venous Thrombosis / drug therapy*
  • Warfarin / administration & dosage
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Warfarin
  • Paclitaxel
  • Cisplatin