Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome

Intern Med. 2019 Jul 15;58(14):2079-2083. doi: 10.2169/internalmedicine.2372-18. Epub 2019 Mar 28.

Abstract

We herein describe a case of Sweet's syndrome (SS) in a patient being treated for pulmonary toxoplasmosis complicated with myelodysplastic syndrome (MDS). The patient's SS developed after the pulmonary toxoplasmosis improved following treatment. We searched his cytokine profiles comprehensively using a bead-based immunoassay. The results showed no elevation of interleukin (IL)-2, interferon (IFN)-γ or IL-17A, and IL-6 was only observed to have increased at the onset of SS, suggesting that the pulmonary toxoplasmosis had been well controlled and that chronic inflammation may have been the cause of SS. Pulmonary toxoplasmosis is an extremely rare occurrence. The cytokine profile can help to clarify the pathological condition of SS and MDS complicated with severely invasive infectious diseases.

Keywords: Sweet's syndrome; cytometric bead array; myelodysplastic syndrome; toxoplasmosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiprotozoal Agents / therapeutic use*
  • Cytokines / blood*
  • Female
  • Humans
  • Myelodysplastic Syndromes / blood*
  • Myelodysplastic Syndromes / complications*
  • Sweet Syndrome / blood*
  • Sweet Syndrome / complications*
  • Toxoplasmosis / drug therapy*

Substances

  • Antiprotozoal Agents
  • Cytokines