This study analyzed the moderating effect of the communication behavior that impacts the care burden of nurses who care for people with behavioral and psychological symptoms of dementia (BPSD). Through the Johnson-Neyman method and SPSS PROCESS Macro, the moderating effect of communication behavior was analyzed. The results showed that communication behavior has a moderating effect on the care burden of nurses of people with BPSD. The results of this study can provide basic data for the development and evaluation of the communication behavior program to reduce the care burden of nurses.