Prometheus Unbound in Ya(p) Heart

Jan W Buikema; Sean M Wu

doi:10.1016/j.devcel.2019.03.007

Prometheus Unbound in Ya(p) Heart

Dev Cell. 2019 Mar 25;48(6):741-742. doi: 10.1016/j.devcel.2019.03.007.

Authors

Jan W Buikema¹, Sean M Wu²

Affiliations

¹ Department of Cardiology, Utrecht Regenerative Medicine Center, University Utrecht, University Medical Center Utrecht, Utrecht University, 3508 GA Utrecht, the Netherlands; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: smwu@stanford.edu.

PMID: 30913402
DOI: 10.1016/j.devcel.2019.03.007

Abstract

The adult mammalian heart, unlike in some amphibian and fish species, is generally considered a post-mitotic organ. In this issue of Developmental Cell, Monroe et al. (2019) show that the expression of constitutively active YAP induces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering chromatin accessibility.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Cell Proliferation
Chromatin*
Myocytes, Cardiac
Signal Transduction*

Substances

Chromatin

Grants and funding

DP1 LM012179/LM/NLM NIH HHS/United States