Farnesoid X receptor: An important factor in blood glucose regulation

Yangfeng Hou; Wenjing Fan; Wenling Yang; Abdul Qadir Samdani; Ampadu Okyere Jackson; Shunlin Qu

doi:10.1016/j.cca.2019.03.1626

Farnesoid X receptor: An important factor in blood glucose regulation

Clin Chim Acta. 2019 Aug:495:29-34. doi: 10.1016/j.cca.2019.03.1626. Epub 2019 Mar 22.

Authors

Yangfeng Hou¹, Wenjing Fan², Wenling Yang¹, Abdul Qadir Samdani³, Ampadu Okyere Jackson⁴, Shunlin Qu⁵

Affiliations

¹ Clinic Medicine Department, Hengyang Medical School, University of South China, Hengyang City, Hunan Province 421001, PR China.
² Pathophysiology Department, University of South China, Hengyang City, Hunan Province 421001, PR China; Emergency Department, The Second Affiliated Hospital, University of South China, Hengyang City, Hunan Province 421001, PR China.
³ Spinal Surgery Department, The First Affiliated Hospital, University of South China, Hengyang City, Hunan Province 421001, PR China.
⁴ International College, Hengyang Medical School, University of South China, Hengyang City, Hunan Province 421001, PR China.
⁵ Pathophysiology Department, University of South China, Hengyang City, Hunan Province 421001, PR China. Electronic address: qushunlin78@126.com.

PMID: 30910597
DOI: 10.1016/j.cca.2019.03.1626

Abstract

Farnesoid X receptor (FXR) is a transcription factor that can be activated by bile acid as well as influenced bile acid metabolism. β-cell bile acid metabolism is mediated by FXR and closely related to the regulation of blood glucose (BG). FXR can regulate BG through multiple pathways. This review summarises recent studies on FXR regulation of BG balance via bile acid regulation, lowering glucagon-like peptide-1 (GLP-1), inhibiting gluconeogenesis, increasing insulin secretion and enhancing insulin sensitivity. In addition, the current review provides additional insight into the relationship between FXR and BG which may provide a new theoretical basis for further study on the role of FXR.

Keywords: Blood glucose; Farnesoid X receptor; Glycometabolism.

Publication types

Review

MeSH terms

Animals
Bile Acids and Salts / metabolism
Blood Glucose / metabolism*
Gluconeogenesis
Humans
Insulin / metabolism
Receptors, Cytoplasmic and Nuclear / metabolism*

Substances

Bile Acids and Salts
Blood Glucose
Insulin
Receptors, Cytoplasmic and Nuclear
farnesoid X-activated receptor