Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach

Chin J Nat Med. 2019 Mar;17(3):227-230. doi: 10.1016/S1875-5364(19)30025-1.

Abstract

Two new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC50 being 37.41 μmol·L-1.

Keywords: Anti-inflammatory; Limonoid; Melia azedarach; Meliaceae.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Fruit / chemistry
  • Limonins / chemistry*
  • Limonins / isolation & purification
  • Limonins / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Melia azedarach / chemistry*
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Limonins
  • Nitric Oxide