High mitochondrial Ca2+ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP)

Saverio Marchi; Veronica Angela Maria Vitto; Simone Patergnani; Paolo Pinton

doi:10.1080/15384101.2019.1598729

High mitochondrial Ca²⁺ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP)

Cell Cycle. 2019 Apr;18(8):914-916. doi: 10.1080/15384101.2019.1598729. Epub 2019 Apr 7.

Authors

Saverio Marchi¹, Veronica Angela Maria Vitto¹, Simone Patergnani^{1

2}, Paolo Pinton^{1

2}

Affiliations

¹ a Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA) , University of Ferrara , Ferrara , Italy.
² b Cecilia Hospital, GVM Care & Research , E.S: Health Science Foundation , Cotignola , Italy.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Calcium / metabolism*
Calcium Channels / metabolism
Calcium-Binding Proteins / genetics
Cation Transport Proteins / genetics
Cell Proliferation / genetics*
Gene Knockdown Techniques
HeLa Cells
Humans
Mitochondria / metabolism*
Mitochondrial Membrane Transport Proteins / antagonists & inhibitors*
Mitochondrial Membrane Transport Proteins / genetics
Mitochondrial Membrane Transport Proteins / metabolism
Mitochondrial Permeability Transition Pore
Neoplasms / metabolism*
Neoplasms / pathology
PC-3 Cells
Transfection

Substances

Calcium Channels
Calcium-Binding Proteins
Cation Transport Proteins
MICU1 protein, human
Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore
mitochondrial calcium uniporter
Calcium

Grants and funding

This work was supported by the Associazione Italiana per la Ricerca sul Cancro [IG‐18624]; Fondazione Telethon [GGP15219/B]; Fondazione Umberto Veronesi; Ministero della Salute [GR-2016-02364602]; Ministero dell'Istruzione dell'Università e della Ricerca [2017E5L5P3].