Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

Dongki Yang; Jaehong Kim

doi:10.3390/cells8030275

Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

Cells. 2019 Mar 22;8(3):275. doi: 10.3390/cells8030275.

Authors

Dongki Yang¹, Jaehong Kim^{2

3}

Affiliations

¹ Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Korea. dkyang@gachon.ac.kr.
² Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea. geretics@gachon.ac.kr.
³ Department of Health Sciences and Technology, Gachon Advanced Institute for Health Science and Technology, Gachon University, Incheon 21999, Korea. geretics@gachon.ac.kr.

Abstract

This review explores the molecular mechanisms that may be responsible for mitochondrial retrograde signalling related metabolic reprogramming in cancer and host cells in the tumour microenvironment and provides a summary of recent updates with regard to the functional modulation of diverse cells in the tumour microenvironment.

Keywords: EMT; metabolic reprogramming; mitochondria; retrograde signalling; tumour microenvironment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Nucleus / metabolism
Humans
Metabolome
Mitochondria / metabolism*
Models, Biological
Signal Transduction*
Tumor Microenvironment*