Abstract
A new macrocyclic diterpenoid, 4β,5β-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts of Anisomeles indica (L.) O. Kuntze (Labiatae). The structure of 1 was established on the basis of spectral evidence. Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.
Keywords:
Anisomeles indica; 4β,5β-dihydroxyovatodiolide; anti-arthritis activity; labiatae.
MeSH terms
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Antibodies, Monoclonal / pharmacology
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CD28 Antigens / immunology
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CD28 Antigens / metabolism
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Diterpenes / chemistry*
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Diterpenes / pharmacology*
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Drug Evaluation, Preclinical / methods
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Drugs, Chinese Herbal / chemistry
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Humans
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Interleukin-2 / metabolism
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Lamiaceae / chemistry*
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Macrocyclic Compounds / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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T-Lymphocytes / drug effects
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T-Lymphocytes / metabolism
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Antibodies, Monoclonal
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CD28 Antigens
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Diterpenes
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Drugs, Chinese Herbal
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IL2 protein, human
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Interleukin-2
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Macrocyclic Compounds
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Plant Extracts
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Tetradecanoylphorbol Acetate