Mass spectrometry-based intraoperative tumor diagnostics

Lorena Hänel; Marcel Kwiatkowski; Laura Heikaus; Hartmut Schlüter

doi:10.4155/fsoa-2018-0087

Mass spectrometry-based intraoperative tumor diagnostics

Future Sci OA. 2019 Mar 7;5(3):FSO373. doi: 10.4155/fsoa-2018-0087. eCollection 2019 Mar.

Authors

Lorena Hänel^{1

2

1

2}, Marcel Kwiatkowski^{1

3

1

3}, Laura Heikaus^{1

1}, Hartmut Schlüter^{1

1}

Affiliations

¹ Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
² Small Animal Clinic, University of Veterinary Medicine Hannover, Bünteweg 9, 30559 Hannover, Germany.
³ Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Abstract

In surgical oncology, decisions regarding the amount of tissue to be removed can have important consequences: the decision between preserving sufficient healthy tissue and eliminating all tumor cells is one to be made intraoperatively. This review discusses the latest technical innovations for a more accurate tumor margin localization based on mass spectrometry. Highlighting the latest mass spectrometric inventions, real-time diagnosis seems to be within reach; focusing on the intelligent knife, desorption electrospray ionization, picosecond infrared laser and MasSpec pen, the current technical status is evaluated critically concerning its scientific and medical practice.

Keywords: DESI; MasSpec pen; PIRL; cancer; iKnife; intraoperative tumor diagnostics; real-time diagnosis; surgery; tumor margin.

Publication types

Review