The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta analysis

Qing Chen; Jin-Yan Zhao; Xiang Xue; Gai-Xia Zhu

doi:10.1016/j.reprotox.2019.03.004

The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta analysis

Reprod Toxicol. 2019 Jun:86:50-55. doi: 10.1016/j.reprotox.2019.03.004. Epub 2019 Mar 21.

Authors

Qing Chen¹, Jin-Yan Zhao¹, Xiang Xue¹, Gai-Xia Zhu²

Affiliations

¹ Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province, PR China.
² Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province, PR China. Electronic address: gaixia_zhu@163.com.

PMID: 30905832
DOI: 10.1016/j.reprotox.2019.03.004

Abstract

Sperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive outcomes. A total of 10 articles retrieved from the databases of PUBMED, MEDLINE, EMBASE and WANFANG were included in the meta-analysis. The results indicated that high sperm DNA fragmentation was signiﬁcantly associated with lower pregnancy rate (RR: 0.34, 95% CI: 0.22-0.52; P < 0.001) and deliveries rate of IUI(RR 0.14, 95% CI:0.04-0.56, P < 0.001). In addition, there was no evidence of publication bias, as suggested by funnel plot, Begg's and Egger's tests. The present meta-analysis indicated that high sperm DNA fragmentation was associated with poor reproductive outcomes of couples undergoing IUI.

Keywords: IUI; Meta-analysis; Pregnancy; Sperm DNA fragmentation.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA Fragmentation*
Female
Humans
Insemination, Artificial
Male
Pregnancy
Pregnancy Outcome*
Spermatozoa*