Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases

Keng-Liang Kuo; Chih-Lung Lin; Chieh-Hsin Wu; Chih-Hui Chang; Hung-Pei Tsai; Joon-Khim Loh; Ann-Shung Lieu; Yu-Feng Su

doi:10.1016/j.wneu.2019.03.113

Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases

World Neurosurg. 2019 Jul:127:e311-e320. doi: 10.1016/j.wneu.2019.03.113. Epub 2019 Mar 21.

Authors

Keng-Liang Kuo¹, Chih-Lung Lin², Chieh-Hsin Wu³, Chih-Hui Chang¹, Hung-Pei Tsai⁴, Joon-Khim Loh⁵, Ann-Shung Lieu³, Yu-Feng Su⁶

Affiliations

¹ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
² Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
³ Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁴ Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁵ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan. Electronic address: suyufeng2000@gmail.com.

PMID: 30904806
DOI: 10.1016/j.wneu.2019.03.113

Abstract

Background: Primary melanocytic neoplasms (PMNs) are rare neoplasms, especially within the central nervous system. Meningeal melanocytomas, a subtype of PMN, are even rarer. Nevus of Ota results from the incomplete migration of melanocytes from the neural crest. Synchronous nevus of Ota and meningeal melanocytoma are infrequently encountered in clinical practice.

Objective: To evaluate and elucidate 12 cases of synchronous meningeal melanocytoma and nevus of Ota, thereby improving the understanding of the relationship between these 2 diseases.

Methods: We reviewed cases and searched the English-language literature from the PubMed database and collected clinical parameters of 12 cases of synchronously occurring nevus of Ota and meningeal melanocytoma.

Results: Among the 12 cases, 90.90% and 91.66% of the lesions were located ipsilaterally and supratentorially, respectively.

Conclusions: Our findings indicated a trend for both types of lesion to be located ipsilaterally and supratentorially. When a patient with nevus of Ota is found to harbor an intracranial neoplasm, the most likely diagnosis is PMN.

Keywords: Case series; Ipsilateral; Meningeal melanocytoma; Nevus of Ota; Supratentorial.

MeSH terms

Brain Neoplasms / pathology
Female
Humans
Melanocytes / pathology*
Melanoma / diagnosis
Melanoma / pathology
Meningeal Neoplasms / diagnosis
Meningeal Neoplasms / pathology*
Middle Aged
Neoplasms, Multiple Primary / pathology
Nevus of Ota / diagnosis
Nevus of Ota / pathology*
Skin Neoplasms / diagnosis
Skin Neoplasms / pathology*