Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

Life Sci. 1986 Aug 18;39(7):645-50. doi: 10.1016/0024-3205(86)90046-9.

Abstract

Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Disaccharidases / antagonists & inhibitors*
  • Female
  • Imino Furanoses
  • In Vitro Techniques
  • Indolizines*
  • Intestinal Mucosa / enzymology
  • Intestines / enzymology*
  • Mannitol / analogs & derivatives
  • Mice
  • Pyrrolidines*
  • Swainsonine

Substances

  • Alkaloids
  • Imino Furanoses
  • Indolizines
  • Pyrrolidines
  • Mannitol
  • 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine
  • Disaccharidases
  • castanospermine
  • Swainsonine