Migrating focal seizures in Autosomal Dominant Sleep-related Hypermotor Epilepsy with KCNT1 mutation

Matteo Cataldi; Lino Nobili; Federico Zara; Romina Combi; Giulia Prato; Thea Giacomini; Valeria Capra; Patrizia De Marco; Luigi Ferini-Strambi; Maria Margherita Mancardi

doi:10.1016/j.seizure.2019.02.019

Migrating focal seizures in Autosomal Dominant Sleep-related Hypermotor Epilepsy with KCNT1 mutation

Seizure. 2019 Apr:67:57-60. doi: 10.1016/j.seizure.2019.02.019. Epub 2019 Mar 7.

Authors

Affiliations

¹ Unit of Child Neuropsychiatry, Department of Neuroscience, Ophthalmology, Genetics and Maternal Infantile Sciences, University of Genoa, Genoa, Italy; Epilepsy Centre, Unit of Child Neuropsychiatry, Department of Medical and Surgical Neurosciences and Rehabilitation, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: matteo_cataldi@hotmail.it.
² Unit of Child Neuropsychiatry, Department of Neuroscience, Ophthalmology, Genetics and Maternal Infantile Sciences, University of Genoa, Genoa, Italy; Department of Neuroscience, Centre of Sleep Medicine, Centre for Epilepsy Surgery, Niguarda Hospital, Milan, Italy. Electronic address: lino.nobili@unige.it.
³ Laboratory of Neurogenetics and Neuroscience, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: federicozara@gaslini.org.
⁴ School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy. Electronic address: romina.combi@unimib.it.
⁵ Epilepsy Centre, Unit of Child Neuropsychiatry, Department of Medical and Surgical Neurosciences and Rehabilitation, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: giulia_prato@hotmail.com.
⁶ Unit of Child Neuropsychiatry, Department of Neuroscience, Ophthalmology, Genetics and Maternal Infantile Sciences, University of Genoa, Genoa, Italy; Epilepsy Centre, Unit of Child Neuropsychiatry, Department of Medical and Surgical Neurosciences and Rehabilitation, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: giacomini.thea@gmail.com.
⁷ Laboratory of Neurogenetics and Neuroscience, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: valeriacapra@gaslini.org.
⁸ Laboratory of Neurogenetics and Neuroscience, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: patriziademarco@gaslini.org.
⁹ Neurology - Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy. Electronic address: ferinistrambi.luigi@hsr.it.
¹⁰ Epilepsy Centre, Unit of Child Neuropsychiatry, Department of Medical and Surgical Neurosciences and Rehabilitation, IRCCS Giannina Gaslini Institute, Genoa, Italy. Electronic address: margheritamancardi@gaslini.org.

PMID: 30903923
DOI: 10.1016/j.seizure.2019.02.019

No abstract available

Keywords: Focal seizure; KCNT1 gene; Migrating seizure; Sleep-related hypermotor epilepsy.

Publication types

Case Reports
Letter

MeSH terms

Child, Preschool
Epilepsies, Partial / diagnosis
Epilepsies, Partial / drug therapy
Epilepsies, Partial / genetics*
Epilepsies, Partial / physiopathology
Humans
Male
Mutation
Nerve Tissue Proteins / genetics*
Parasomnias / diagnosis
Parasomnias / drug therapy
Parasomnias / genetics*
Parasomnias / physiopathology
Pedigree
Potassium Channels, Sodium-Activated / genetics*

Substances

KCNT1 protein, human
Nerve Tissue Proteins
Potassium Channels, Sodium-Activated