The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Anna M Schmoker; Alicia M Ebert; Bryan A Ballif

doi:10.1042/BCJ20190022

The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Biochem J. 2019 Mar 22;476(6):931-950. doi: 10.1042/BCJ20190022.

Authors

Anna M Schmoker¹, Alicia M Ebert², Bryan A Ballif¹

Affiliations

¹ Department of Biology, University of Vermont, 109 Carrigan Drive, 120A Marsh Life Sciences, Burlington, VT 05405, U.S.A. aschmoke@uvm.edu bballif@uvm.edu.
² Department of Biology, University of Vermont, 109 Carrigan Drive, 120A Marsh Life Sciences, Burlington, VT 05405, U.S.A.

PMID: 30902898
DOI: 10.1042/BCJ20190022

Abstract

The discoidin, CUB, and LCCL domain-containing (DCBLD) receptor family are composed of the type-I transmembrane proteins DCBLD1 and DCBLD2 (also ESDN and CLCP1). These proteins are highly conserved across vertebrates and possess similar domain structure to that of neuropilins, which act as critical co-receptors in developmental processes. Although DCBLD1 remains largely uncharacterized, the functional and mechanistic roles of DCBLD2 are emerging. This review provides a comprehensive discussion of this presumed receptor family, ranging from structural and signaling aspects to their associations with cancer, physiology, and development.

Keywords: DCBLD1; DCBLD2; cancer; cell signaling; development; signal transduction.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Humans
Membrane Proteins / metabolism*
Neoplasm Proteins / metabolism*
Neoplasms / metabolism*
Neoplasms / pathology
Signal Transduction*

Substances

DCBLD1 protein, human
DCBLD2 protein, human
Membrane Proteins
Neoplasm Proteins