Is HIF1-a deregulated in malignant salivary neoplasms?

Gene. 2019 Jun 15:701:41-45. doi: 10.1016/j.gene.2019.03.017. Epub 2019 Mar 19.

Abstract

Background: There is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs).

Objective: The current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms.

Patients and methods: The current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR.

Results: No differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups.

Conclusion: The angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.

Keywords: Chemotherapy; Glandular neoplasia; Hypoxia; Salivar.

Publication types

  • Clinical Trial

MeSH terms

  • Biomarkers, Tumor / biosynthesis*
  • Cross-Sectional Studies
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis*
  • Male
  • MicroRNAs / biosynthesis
  • Neoplasm Proteins / biosynthesis*
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / pathology
  • RNA, Neoplasm / biosynthesis
  • Retrospective Studies
  • Salivary Gland Neoplasms* / blood supply
  • Salivary Gland Neoplasms* / metabolism
  • Salivary Gland Neoplasms* / pathology

Substances

  • Biomarkers, Tumor
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • MIRN210 microRNA, human
  • MicroRNAs
  • Neoplasm Proteins
  • RNA, Neoplasm