Background: There is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs).
Objective: The current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms.
Patients and methods: The current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR.
Results: No differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups.
Conclusion: The angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.
Keywords: Chemotherapy; Glandular neoplasia; Hypoxia; Salivar.
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