Retropharyngeal lipostructure in the treatment of velopharyngeal insufficiency: A prospective study and update

Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Jun;136(3):173-177. doi: 10.1016/j.anorl.2019.03.003. Epub 2019 Mar 20.

Abstract

Introduction: Retropharyngeal lipostructure is a recent procedure in velopharyngeal insufficiency (VPI), offering an effective alternative to heavier surgery.

Objectives: To update and assess retropharyngeal lipostructure as a treatment for VPI in the University Hospital Center of Rouen (France).

Type of study: Single-center prospective study, from May 2012 to May 2014.

Patients and methods: Six patients (4 girls, 2 boys) presenting with VPI were treated by retropharyngeal lipostructure. Age at surgery ranged between 6 and 12 years. Four of the patients bore a 22q11 microdeletion. Treatment was indicated in case of Borel-Maisonny type 2b (n=2) or 2m (n=4) despite well-conducted speech therapy and of≥50% velopharyngeal sphincter closure on nasal endoscopy. Patients were assessed preoperatively and at 3 months, by a multidisciplinary team. Borel-Maisonny type was assessed by a speech therapist. Nasality was measured on assisted vocal evaluation (EVA®). Sphincter closure was assessed on dynamic MRI.

Results: Between 6 and 8cm3autologous fat was injected. At 3months, 4 children showed 1-grade improvement in Borel-Maisonny type. Nasality decreased systematically, from a mean 14.5% preoperatively to 10.5% postoperatively. MRI showed improvement in all cases, with complete closure in occlusive vowels in 3 children.

Conclusion: EVA® and MRI provide precise objective assessment of VPI. Retropharyngeal lipostructure is a simple, relatively non-invasive, reproducible technique, providing good results in VPI.

Keywords: 22q11 deletion; Nasality; Retropharyngeal lipostructure; Velopharyngeal insufficiency; Velopharyngeal sphincter.

MeSH terms

  • Adipose Tissue / transplantation*
  • Autografts
  • Child
  • Chromosome Deletion
  • Chromosomes, Human, Pair 22
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Pharynx / surgery
  • Prospective Studies
  • Treatment Outcome
  • Velopharyngeal Insufficiency / classification
  • Velopharyngeal Insufficiency / genetics
  • Velopharyngeal Insufficiency / physiopathology
  • Velopharyngeal Insufficiency / surgery*
  • Velopharyngeal Sphincter / diagnostic imaging
  • Velopharyngeal Sphincter / physiopathology
  • Velopharyngeal Sphincter / surgery*
  • Voice Quality

Supplementary concepts

  • Chromosome 22, microdeletion 22 q11