Context Matters: RNF168 Connects with PALB2 to Rewire Homologous Recombination in BRCA1 Haploinsufficiency

Antonio Porro; Alessandro A Sartori

doi:10.1016/j.molcel.2019.03.005

Context Matters: RNF168 Connects with PALB2 to Rewire Homologous Recombination in BRCA1 Haploinsufficiency

Mol Cell. 2019 Mar 21;73(6):1089-1091. doi: 10.1016/j.molcel.2019.03.005.

Authors

Antonio Porro¹, Alessandro A Sartori²

Affiliations

¹ Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
² Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Electronic address: sartori@imcr.uzh.ch.

PMID: 30901561
DOI: 10.1016/j.molcel.2019.03.005

Abstract

In this issue of Molecular Cell, Zong et al. (2019) reveal RNF168-driven chromatin ubiquitylation as a key back-up mechanism to sustain homologous recombination (HR) independently of BRCA1. These findings provide new clues to carcinogenesis and cancer therapy in BRCA1 heterozygous mutation carriers.

Publication types

Comment

MeSH terms

BRCA1 Protein / genetics
Cell Line, Tumor
Chromatin*
Haploinsufficiency*
Homologous Recombination
Ubiquitination

Substances

BRCA1 Protein
Chromatin