As the core of cellular immunotherapy, T cells are important aspects of research and treatment of lung cancer. IL-6 is a costimulatory signal factor of T cells that is directly targeted by lung cancer stem cells. As a highly expressed cytokine in lung cancer cells, IL-6 plays an important role in variety of biological activities such as tumor occurrence, development, invasion and metastasis. This article reviews the research progress on IL-6 in lung cancer, including cancer development and progression, and the therapeutic sensitivity of lung cancer.
T细胞作为细胞免疫疗法的核心，在肺癌研究及治疗中占据着重要地位。IL-6是目前已知的肺癌干细胞直接靶向的重要T细胞共刺激信号因子，其作为肺癌细胞中高表达的细胞因子，在肿瘤的发生、发展、侵袭、转移等一系列生物学行为中发挥着重要作用。本文对近年来IL-6在肺癌领域的研究进展，包括IL-6在肺癌发生和进展中的作用及其在肺癌治疗敏感性中的作用进行了综述。