18 Fluorodeoxyglucose-positron emission tomography/computed tomography features of suspected solitary pulmonary lesions in breast cancer patients following previous curative treatment

Thorac Cancer. 2019 May;10(5):1086-1095. doi: 10.1111/1759-7714.13049. Epub 2019 Mar 21.

Abstract

Background: Differentiating pulmonary metastasis from primary lung cancer can be challenging in patients with breast malignancy. This study aimed to characterize the imaging features of 18 fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG-PET/CT) for distinguishing between these diseases.

Methods: We enrolled 52 patients who received curative treatment for breast cancer but later presented with suspected solitary pulmonary lesions (SPLs) and subsequently underwent 18 F-FDG-PET/CT to investigate.

Results: Subsolid lesions, ill-defined borders, lung lesions with negative maximum standardized uptake value, and lesions without 18 F-FDG-PET/CT-diagnosed hilar and/or mediastinal lymph nodes and pleural metastases were more likely to be associated with primary lung cancer.

Conclusions: CT border, FDG uptake, hilar and/or mediastinal lymph node metastasis, and pleural metastasis are potential markers for diagnosis.

Keywords: 18Fluorodeoxyglucose-positron emission tomography/computed tomography; breast cancer metastasis; lung cancer; solitary pulmonary lesion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / complications*
  • Breast Neoplasms / therapy
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Image Processing, Computer-Assisted
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / etiology*
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Staging
  • Odds Ratio
  • Positron Emission Tomography Computed Tomography*
  • Solitary Pulmonary Nodule / diagnosis*
  • Solitary Pulmonary Nodule / etiology*

Substances

  • Fluorodeoxyglucose F18