Defining Barriers that Impede Choices

Tonya J Webb; Amy S Weinmann

doi:10.1016/j.immuni.2019.02.021

Defining Barriers that Impede Choices

Immunity. 2019 Mar 19;50(3):542-544. doi: 10.1016/j.immuni.2019.02.021.

Authors

Tonya J Webb¹, Amy S Weinmann²

Affiliations

¹ Department of Microbiology and Immunology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA. Electronic address: twebb@som.umaryland.edu.
² Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: weinmann@uab.edu.

PMID: 30893582
DOI: 10.1016/j.immuni.2019.02.021

Abstract

Committing to a differentiation pathway means leaving alternative pathways behind. Adoue et al. (2019) report that the H3K9-methyltrasferase Setdb1 plays a role in inhibiting the Th1 program in committed Th2 cells, and mechanistically, its role might relate to the selective targeting of endogenous retroviruses adjacent to Th1 enhancers.

Publication types

Comment

MeSH terms

Cell Differentiation
Cell Lineage
Endogenous Retroviruses*
Histone Methyltransferases
Histone-Lysine N-Methyltransferase / genetics
Th2 Cells

Substances

Histone Methyltransferases
Histone-Lysine N-Methyltransferase