The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes

Int J Immunogenet. 2019 Jun;46(3):146-151. doi: 10.1111/iji.12422. Epub 2019 Mar 20.

Abstract

LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1/LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS.

Keywords: HLA-B27; KIR; LILR; ankylosing spondylitis; genetics.

MeSH terms

  • Adaptive Immunity / genetics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Immunity, Innate / genetics
  • Leukocyte Immunoglobulin-like Receptor B1 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Receptors, Immunologic / genetics*
  • Receptors, KIR / genetics*
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / immunology*

Substances

  • Antigens, CD
  • LILRA3 protein, human
  • LILRB1 protein, human
  • Leukocyte Immunoglobulin-like Receptor B1
  • Receptors, Immunologic
  • Receptors, KIR