Pushing the boundaries of in situ hybridisation for mRNA demonstration: demonstration of kappa and lambda light chain restriction in follicular lymphoma

Br J Biomed Sci. 2019 Jul;76(3):143-146. doi: 10.1080/09674845.2019.1598100. Epub 2019 Apr 26.

Authors

A Warford¹, M Rahman¹, J A Hughes², G Gerrard³, D A Ribeiro¹

Affiliations

¹ a Life sciences , University of Westminster , London , UK.
² b Advanced Diagnostics , University College London , London , UK.
³ c Sarah Cannon Molecular Diagnostics , HCA Healthcare , London , UK.

PMID: 30892145
DOI: 10.1080/09674845.2019.1598100

No abstract available

Keywords: Branched DNA hybridisation; follicular lymphoma; immunocytochemistry; light chain restriction; mRNA.

MeSH terms

Humans
Immunoglobulin kappa-Chains / genetics*
Immunoglobulin kappa-Chains / immunology
Immunoglobulin lambda-Chains / genetics*
Immunoglobulin lambda-Chains / immunology
In Situ Hybridization / methods*
Lymphoma, Follicular / diagnosis
Lymphoma, Follicular / genetics*
Lymphoma, Follicular / immunology
RNA, Messenger / genetics*
RNA, Messenger / metabolism

Substances

Immunoglobulin kappa-Chains
Immunoglobulin lambda-Chains
RNA, Messenger