microRNAs: New prognostic, diagnostic, and therapeutic biomarkers in cervical cancer

J Cell Physiol. 2019 Aug;234(10):17064-17099. doi: 10.1002/jcp.28457. Epub 2019 Mar 19.

Abstract

Cervical cancer is as a kind of cancer beginning from the cervix. Given that cervical cancer could be observed in women who infected with papillomavirus, regular oral contraceptives, and multiple pregnancies. Early detection of cervical cancer is one of the most important aspects of the therapy of this malignancy. Despite several efforts, finding and developing new biomarkers for cervical cancer diagnosis are required. Among various prognostic, diagnostic, and therapeutic biomarkers, miRNA have been emerged as powerful biomarkers for detection, treatment, and monitoring of response to therapy in cervical cancer. Here, we summarized various miRNAs as an employable platform for prognostic, diagnostic, and therapeutic biomarkers in the treatment of cervical cancer.

Keywords: Human papillomavirus; cervical cancer; diagnosis; exosome; microRNA; therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics*
  • Early Detection of Cancer
  • Female
  • Humans
  • MicroRNAs*
  • Prognosis
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / genetics*

Substances

  • Biomarkers, Tumor
  • MicroRNAs