Regulation of type I interferon: It's HIP to be K2

Sonja M Best; Sanket S Ponia

doi:10.1126/scisignal.aaw8549

Regulation of type I interferon: It's HIP to be K2

Sci Signal. 2019 Mar 19;12(573):eaaw8549. doi: 10.1126/scisignal.aaw8549.

Authors

Sonja M Best¹, Sanket S Ponia²

Affiliations

¹ Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA. sbest@niaid.nih.gov.
² Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA.

PMID: 30890660
DOI: 10.1126/scisignal.aaw8549

Abstract

Uncontrolled expression of type I interferon (IFN-I) drives autoimmunity, necessitating the need for tight regulation. In this issue, Cao et al reveal a role for the kinase HIPK2 in the transcriptional control of IFN-I during antiviral immune responses.

Publication types

Research Support, N.I.H., Intramural
Review
Comment

MeSH terms

Antiviral Agents*
Autoimmunity
Gene Expression Regulation
Interferon Type I*

Substances

Antiviral Agents
Interferon Type I