Identification of a novel allele, HLA-DPB1*417:01:02, in an African American deceased donor

HLA. 2019 Jul;94(1):88. doi: 10.1111/tan.13526. Epub 2019 Mar 27.

Abstract

HLA-DPB1*417:01:02 differs from HLA-DPB1*417:01:01 by a synonymous nucleotide substitution at codon 43.

Keywords: Linkage Biosciences LinkSeq; Pacific Biosciences single molecule real-time DNA sequencing; new allele.

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Base Sequence
  • Black or African American / genetics*
  • Codon*
  • HLA-DP beta-Chains / genetics*
  • Histocompatibility Testing / methods*
  • Humans
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA / methods*
  • Sequence Homology
  • Tissue Donors

Substances

  • Codon
  • HLA-DP beta-Chains
  • HLA-DPB1 antigen