MST Kinases and Metabolism

Endocrinology. 2019 May 1;160(5):1111-1118. doi: 10.1210/en.2018-00898.

Abstract

Since the discovery of the mammalian sterile twenty (MST) kinase family of proteins (MST1/STK4, MST2/STK3, MST3/STK24, and SOK1/STK25), much has been done that adds to our knowledge of their structure, regulation, and function. In the last few years, a series of articles has unveiled a previous unknown relation of these kinases with metabolic regulation and the homeostasis of metabolic tissues. The aim of this review is to bring together this body of data to provide a detailed picture of the current knowledge about these proteins, metabolism, and some of the associated diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / enzymology*
  • Adipose Tissue / metabolism
  • Animals
  • Energy Metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Neoplasms / enzymology*
  • Neoplasms / metabolism
  • Protein Serine-Threonine Kinases / metabolism*
  • Serine-Threonine Kinase 3

Substances

  • Intracellular Signaling Peptides and Proteins
  • STK24 protein, human
  • STK4 protein, human
  • Protein Serine-Threonine Kinases
  • STK25 protein, human
  • STK3 protein, human
  • Serine-Threonine Kinase 3