Rationale: A gouty tophus, arising from the deposition of monosodium urate crystals (MSU), rarely occurs in the nasal bridge. There have been only 7 documented cases of a gouty tophus in the nasal bridge from 1978 to 2018 in English-language literature.
Patient concerns: A 65-year-old male had a chief complaint of a lump in the nasal bridge that was slowly growing for over 1 year.
Diagnosis: MSU crystals were confirmed through ultrasonography (US) and pathological examinations.
Interventions: A cosmetically less destructive method, ultrasound-guided fine needle aspiration cytology (FNAC) was used to approach the mass lesion of nasal bridge.
Outcomes: The diagnosis was confirmed as a gouty tophus without performing a nasal subdermal exploration.
Lessons: This case report is the first use of US with FNAC to approach and diagnosed a gouty tophus in the nasal bridge.