Loss of the tRNALysCUU encoding gene, Chr-11 tRNA-Lys-CUU, is not associated with Type 2 diabetes mellitus

Biomark Med. 2019 Mar;13(4):259-266. doi: 10.2217/bmm-2018-0322. Epub 2019 Mar 18.

Abstract

Aim: To investigate the presence/absence of the Chr-11 tRNA-Lys-CUU gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).

Methods: We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of Chr-11 tRNA-Lys-CUU by polymerase chain reaction analyses.

Results: Approximately one third of the population lacked Chr-11 tRNA-Lys-CUU. We did not observe a statistically significant association between the presence/absence of Chr-11 tRNA-Lys-CUU and T2DM.

Conclusion: The genotypic distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.

Keywords: PCR; T2DM; Type 2 diabetes mellitus; biomarker; gene translation; genotypic profiling; insulin; tRNA; tRNA gene; tRNA-Lys-CUU.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / analysis*
  • Case-Control Studies
  • Chromosomes, Human, Pair 11 / genetics*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Gene Deletion*
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • RNA, Transfer, Lys / genetics*
  • Spain / epidemiology

Substances

  • Biomarkers
  • RNA, Transfer, Lys