Promising anti-diabetic effect of dextran sulfate sodium: Is it its clinical come back?

Mohamed H Noureldein; Batoul A Dia; Ali I Nabbouh; Assaad A Eid

doi:10.1016/j.diabres.2019.03.016

Promising anti-diabetic effect of dextran sulfate sodium: Is it its clinical come back?

Diabetes Res Clin Pract. 2020 Jan:159:107661. doi: 10.1016/j.diabres.2019.03.016. Epub 2019 Mar 14.

Authors

Mohamed H Noureldein¹, Batoul A Dia¹, Ali I Nabbouh¹, Assaad A Eid²

Affiliations

¹ Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
² Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon. Electronic address: ae49@aub.edu.lb.

PMID: 30880091
DOI: 10.1016/j.diabres.2019.03.016

Abstract

Clinical studies showed that dextran sulfate sodium (DSS) alleviates stroke, diabetic retinopathy and hypercholesterolemia, yet its mechanism of action was unrevealed. This study show that DSS reduces hyperglycemia, plasma insulin and enhances glucose utilization by attenuating ROS production, suggesting a novel therapeutic use of DSS in diabetes and its complication.

Keywords: Diabetes; Diabetes complications; Hypoglycemic agents.

MeSH terms

Animals
Dextran Sulfate / pharmacology
Dextran Sulfate / therapeutic use*
Diabetes Mellitus / drug therapy*
Humans
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / therapeutic use*
Male
Mice

Substances

Hypoglycemic Agents
Dextran Sulfate