Solvent-free production of phthalated cashew gum for green synthesis of antimicrobial silver nanoparticles

Antônia Carla de Jesus Oliveira; Alyne Rodrigues de Araújo; Patrick Veras Quelemes; Daniela Nadvorny; José Lamartine Soares-Sobrinho; José Roberto Sousa de Almeida Leite; Edson Cavalcanti da Silva-Filho; Durcilene Alves da Silva

doi:10.1016/j.carbpol.2019.02.033

Solvent-free production of phthalated cashew gum for green synthesis of antimicrobial silver nanoparticles

Carbohydr Polym. 2019 Jun 1:213:176-183. doi: 10.1016/j.carbpol.2019.02.033. Epub 2019 Feb 14.

Authors

Antônia Carla de Jesus Oliveira¹, Alyne Rodrigues de Araújo², Patrick Veras Quelemes², Daniela Nadvorny³, José Lamartine Soares-Sobrinho³, José Roberto Sousa de Almeida Leite⁴, Edson Cavalcanti da Silva-Filho⁵, Durcilene Alves da Silva⁶

Affiliations

¹ Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI, Brazil; Núcleo de Controle de Qualidade de Medicamentos e Correlatos, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Brazil.
² Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI, Brazil.
³ Núcleo de Controle de Qualidade de Medicamentos e Correlatos, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Brazil.
⁴ Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI, Brazil; Área Morfologia, Faculdade de Medicina, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, Brazil.
⁵ Laboratório Interdisciplinar de Materiais Avançados, Universidade Federal do Piauí, Brazil.
⁶ Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, Parnaíba, PI, Brazil. Electronic address: durcileneas@gmail.com.

PMID: 30879658
DOI: 10.1016/j.carbpol.2019.02.033

Abstract

This work describes a solvent-free method for the chemical modification of cashew gum (Anacardium occidentale L.) using phthalic anhydride in different proportions with different reaction times. Four biopolymers were synthesized and characterized by FTIR, NMR, and elemental analysis. A computational chemistry study was conducted to understand better the reaction. Phthalated cashew gum was used in preparation of silver nanoparticles (AgNPs) by a conventional route, using sodium borohydride (NaBH₄) as reducing agent, and for green route. AgNPs were evaluated for antimicrobial activity and characterized by UV-Vis spectroscopy, FTIR, nanoparticle tracking analysis, Zeta Potential analysis, and atomic force microscopy. AgNPs produced by the green route had an average size of 51.9 nm and Zeta Potential of -55.8 mV, and AgNPs produced by the conventional method had an average size of 47.7 nm and Zeta Potential of -39.3 mV. AgNPs synthesized using phthalated cashew gum showed antimicrobial activity against Staphylococcus aureus and Escherichia coli.

Keywords: Anacardium occidentale L.; Antimicrobial activity.; Green synthesis; Phthalated cashew gum; Silver nanoparticles.

MeSH terms

Anacardium / chemistry*
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Dose-Response Relationship, Drug
Escherichia coli / drug effects*
Metal Nanoparticles / chemistry*
Microbial Sensitivity Tests
Phthalic Acids / chemistry
Silver / chemistry
Silver / pharmacology*
Staphylococcus aureus / drug effects*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Phthalic Acids
Silver
phthalic acid