Death of captive-bred vultures caused by flunixin poisoning in Italy

Environ Toxicol Pharmacol. 2019 May:68:91-93. doi: 10.1016/j.etap.2019.03.011. Epub 2019 Mar 11.

Abstract

Among non steroidal anti-inflammatory drugs (NSAIDs) diclofenac is considered the main cause for the decline of vulture populations in the Indian subcontinent since the '90 s. Chemical analysis showed high levels of flunixin (31,350 μg/kg) in beef which three captive Gyps vultures fed on, later dying with severe visceral gout. Levels in dead vultures' organs and tissues ranged from 4 to 38.5 μg/kg. The typical lesions and the concentrations found in beef indicate flunixin as the cause of death. This is the first observational study which correlates the concentration of flunixin in the meat ingested with that found in tissues of vultures.

Keywords: Flunixin; Gyps vultures; Italy; NSAID; Poisoning; Visceral gout.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Anti-Inflammatory Agents, Non-Steroidal / poisoning*
  • Cattle
  • Clonixin / analogs & derivatives*
  • Clonixin / analysis
  • Clonixin / poisoning
  • Falconiformes*
  • Food Chain
  • Gout / chemically induced
  • Heart / drug effects
  • Italy
  • Kidney / drug effects
  • Kidney / pathology
  • Meat / analysis
  • Meat / poisoning*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • flunixin
  • Clonixin