Exploration of TiO2 nanoparticle mediated microdynamic therapy on cancer treatment

Abstract

Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO₂ nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy) as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO₂ nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W) microwave (MW) irradiation for 5 min. The high photocatalytic activity of TiO₂ nanoparticles efficiently utilizes the microwave-induced plasmonic effect for the formation of reactive oxygen species (ROS). Furthermore, TiO₂ nanoparticles exhibit a higher cytotoxicity on cancer cells (osteosarcoma UMR-106 cells) than on normal cells (mouse fibroblast L929 cells). The effectiveness of TiO₂ nanoparticles for microwave induced radical therapy demonstrates that this is a new landmark approach to treating cancers.

Keywords: Microdynamic therapy; Osteosarcoma; Reactive oxygen species; TiO(2) nanoparticles.