Transmission of CMV, HTLV-1, and HIV through breastmilk

Andrew J Prendergast; Ameena E Goga; Catriona Waitt; Antoine Gessain; Graham P Taylor; Nigel Rollins; Elaine J Abrams; E Hermione Lyall; Philippe Van de Perre

doi:10.1016/S2352-4642(19)30024-0

Transmission of CMV, HTLV-1, and HIV through breastmilk

Lancet Child Adolesc Health. 2019 Apr;3(4):264-273. doi: 10.1016/S2352-4642(19)30024-0.

Authors

Andrew J Prendergast¹, Ameena E Goga², Catriona Waitt³, Antoine Gessain⁴, Graham P Taylor⁵, Nigel Rollins⁶, Elaine J Abrams⁷, E Hermione Lyall⁸, Philippe Van de Perre⁹

Affiliations

¹ Blizard Institute, Queen Mary University of London, London, UK; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. Electronic address: a.prendergast@qmul.ac.uk.
² South African Medical Research Council, Cape Town, South Africa; Department of Paediatrics, University of Pretoria, Hatfield, South Africa.
³ Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK; Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.
⁴ EPVO Unit, Institut Pasteur, Paris, France.
⁵ Section of Virology, Imperial College London, London, UK.
⁶ Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.
⁷ ICAP at Columbia, Mailman School of Public Health, and Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
⁸ Department of Paediatrics, Imperial College Healthcare NHS Trust, London, UK.
⁹ Pathogenesis and Control of Chronic Infection, INSERM, University Montpellier, Etablissement Français du Sang, CHU de Montpellier, Montpellier, France.

PMID: 30878119
DOI: 10.1016/S2352-4642(19)30024-0

Abstract

Breastfeeding is a crucial child survival intervention. However, the potential for transmission of viral infections from mother to child presents the dilemma of how best to interpret the benefits and risks of breastfeeding in different settings. In this Review, we compare the transmission dynamics, risk factors, and outcomes of infection with three chronic viruses transmitted through breastmilk: cytomegalovirus, human T-cell lymphotropic virus type 1, and HIV. We provide an overview of intervention approaches and discuss scientific, policy, and programming gaps in the understanding of these major global infections.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Breast Feeding*
Cytomegalovirus Infections / transmission*
HIV Infections / transmission*
HTLV-I Infections / transmission*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical* / prevention & control

Grants and funding

001/WHO_/World Health Organization/International