Mouse models in modeling aging and cancer

Haili Li; Chuanyu Wei; Ruoyu Zhou; Boyuan Wang; Yongjin Zhang; Chihao Shao; Ying Luo

doi:10.1016/j.exger.2019.03.002

Mouse models in modeling aging and cancer

Exp Gerontol. 2019 Jun:120:88-94. doi: 10.1016/j.exger.2019.03.002. Epub 2019 Mar 12.

Authors

Haili Li¹, Chuanyu Wei², Ruoyu Zhou¹, Boyuan Wang², Yongjin Zhang², Chihao Shao², Ying Luo³

Affiliations

¹ Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Lab of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
² Lab of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
³ Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Lab of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address: yingluo@kmust.edu.cn.

PMID: 30876950
DOI: 10.1016/j.exger.2019.03.002

Abstract

Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Many of these genetic pathways are also shared by aging and cancer. The mouse models generated to study these pathways might manifest either aging or cancer phenotypes, sometimes both, which in deed has worked as a good model system in understanding the correlation between aging and cancer. Here, we reviewed these mouse models that were generated to model aging or cancer. These mouse models might help us put those related pathways in context and discover essential interactions in cancer and aging regulation.

Keywords: Aging; Cancer; Mouse models.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging*
Animals
DNA Damage
Disease Models, Animal
Inflammation / complications
Mice
Neoplasms / etiology*
Progeria / etiology
Telomerase / genetics
Telomere / physiology*
Telomeric Repeat Binding Protein 2 / physiology

Substances

TRF2 protein, mouse
Telomeric Repeat Binding Protein 2
Telomerase