This work demonstrates thermal regeneration of gratings inscribed in a new type of multi-material glass-based photosensitive fiber. And isothermal annealing procedure has been carried out on a type-I seed grating (SG) imprinted in erbium-doped zirconia-yttria-alumina-germanium (Er-ZYAG) silica glass-based fiber, which is initiated from room temperature of 25°C up to 900°C. The findings show that the created regenerated grating (RG) has an ultrahigh thermal regeneration ratio with a value of 0.72.