[BRCAmutations more frequent in people of Jewish ancestry]

Ned Tijdschr Geneeskd. 2019 Mar 1:163:D3663.
[Article in Dutch]

Abstract

Three BRCA1/BRCA2 mutations occur more frequently in the Jewish population than in the general population. In Jewish patients with breast cancer about 10% of cases are caused by one of these mutations; consequently, all patients with breast cancer and who are of Jewish ancestry, or their healthy family members, are eligible for genetic testing.

MeSH terms

  • Adult
  • BRCA1 Protein / genetics*
  • BRCA1 Protein / metabolism
  • BRCA2 Protein / genetics*
  • BRCA2 Protein / metabolism
  • Breast Neoplasms / genetics*
  • Female
  • Genetic Testing
  • Humans
  • Jews / genetics*
  • Middle Aged
  • Mutation*
  • Ovarian Neoplasms / genetics*

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human