Ileal pouch-anal anastomosis with fluorescence angiography: a case-matched study

Colorectal Dis. 2019 Jul;21(7):827-832. doi: 10.1111/codi.14611. Epub 2019 Apr 2.

Abstract

Aim: An anastomotic leak in ileoanal pouch surgery may lead to pouch failure. Constructing a tension-free ileal pouch-anal anastomosis (IPAA) reduces this risk but can be technically challenging, balancing pouch vascularization with ileal mesenteric length and site of vessel ligation. Fluorescence angiography (FA) may help the clinician make a more balanced judgement.

Methods: Thirty-two patients undergoing minimally invasive completion proctectomy with FA-guided IPAA at two academic centres were matched and compared on a 1:1 basis to a historical group undergoing the same procedure without the use of this technique.

Results: Ligation of the ileocolic vessels was safely performed in 15/32 (47%) of FA patients compared with 5/32 (16%) of historical controls. One patient underwent intra-operative IPAA reconstruction after FA detected ischaemia. No anastomotic leak occurred with FA but there was only one in the historical controls (P = 0.31). The postoperative complication rate was similar between the two groups (P = 0.60).

Conclusion: FA is applicable to IPAA surgery and may help to reduce perfusion-related anastomotic leaks. A prospective randomized trial is warranted.

Keywords: familial adenomatous polyposis; fluorescence angiography; indocyanine green; pouch surgery; restorative proctocolectomy; ulcerative colitis.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Anastomotic Leak / etiology
  • Anastomotic Leak / prevention & control*
  • Case-Control Studies
  • Colon / blood supply
  • Databases, Factual
  • Female
  • Fluorescein Angiography / methods*
  • Humans
  • Ileum / blood supply
  • Ligation / methods*
  • Male
  • Middle Aged
  • Proctocolectomy, Restorative / adverse effects
  • Proctocolectomy, Restorative / methods*
  • Prospective Studies
  • Retrospective Studies
  • Treatment Outcome