Card9 as a critical regulator of tumor development

Xiaoming Zhong; Bin Chen; Liang Yang; Zhiwen Yang

doi:10.1016/j.canlet.2019.03.001

Card9 as a critical regulator of tumor development

Cancer Lett. 2019 Jun 1:451:150-155. doi: 10.1016/j.canlet.2019.03.001. Epub 2019 Mar 11.

Authors

Xiaoming Zhong¹, Bin Chen², Liang Yang³, Zhiwen Yang⁴

Affiliations

¹ Jiangxi Province Tumor Hospital, Nanchang, China.
² Surgery Department, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China.
³ Nanjing Medical University, The Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Nanjing, China.
⁴ Department of Pharmacy, Songjiang Hospital Affiliated Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: yangzhiwen2009@sina.com.

PMID: 30872079
DOI: 10.1016/j.canlet.2019.03.001

Abstract

Caspase recruitment domain-containing protein 9 (Card9) is a myeloid cell-specific signaling protein that plays a critical role in NF-κB and MAPK activation. This leads to initiation of the inflammatory cytokine cascade, and elicits the host immune response against microbial invasion, especially in fungal infection. Current research indicates that Card9 plays an important role in tumor progression. Here, we review the data from preclinical and clinical studies of Card9 and suggest the potential for Card9-targeted interventions in the prevention or treatment of certain tumors.

Keywords: Card9; Macrophages; Target therapy; Tumor growth.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
CARD Signaling Adaptor Proteins / metabolism*
Humans
MAP Kinase Signaling System
NF-kappa B / metabolism
Neoplasms / metabolism
Neoplasms / pathology*
Neoplasms / therapy
Treatment Outcome

Substances

CARD Signaling Adaptor Proteins
CARD9 protein, human
NF-kappa B