Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Priyadharshini Devarajan; Susan L Swain

doi:10.1016/j.chom.2019.02.009

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Cell Host Microbe. 2019 Mar 13;25(3):354-355. doi: 10.1016/j.chom.2019.02.009.

Authors

Priyadharshini Devarajan¹, Susan L Swain²

Affiliations

¹ Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01604, USA.
² Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01604, USA. Electronic address: susan.swain@umassmed.edu.

Abstract

In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.

Publication types

Comment

MeSH terms

Antibodies, Viral / immunology
Cross Reactions
Humans
Influenza Vaccines / immunology*
Influenza, Human / immunology*
Vaccination

Substances

Antibodies, Viral
Influenza Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding