Background: Medications are frequently used for treating schizophrenia, however, anti-psychotic drug use is known to lead to cases of pneumonia. The purpose of our study is to build a model for predicting hospital-acquired pneumonia among schizophrenic patients by adopting machine learning techniques.
Methods: Data related to a total of 185 schizophrenic in-patients at a Taiwanese district mental hospital diagnosed with pneumonia between 2013 ~ 2018 were gathered. Eleven predictors, including gender, age, clozapine use, drug-drug interaction, dosage, duration of medication, coughing, change of leukocyte count, change of neutrophil count, change of blood sugar level, change of body weight, were used to predict the onset of pneumonia. Seven machine learning algorithms, including classification and regression tree, decision tree, k-nearest neighbors, naïve Bayes, random forest, support vector machine, and logistic regression were utilized to build predictive models used in this study. Accuracy, area under receiver operating characteristic curve, sensitivity, specificity, and kappa were used to measure overall model performance.
Results: Among the seven adopted machine learning algorithms, random forest and decision tree exhibited the optimal predictive accuracy versus the remaining algorithms. Further, six most important risk factors, including, dosage, clozapine use, duration of medication, change of neutrophil count, change of leukocyte count, and drug-drug interaction, were also identified.
Conclusions: Although schizophrenic patients remain susceptible to the threat of pneumonia whenever treated with anti-psychotic drugs, our predictive model may serve as a useful support tool for physicians treating such patients.
Keywords: Clozapine; Machine learning; Pneumonia; Risk factors; Schizophrenia.