Phaeohyphomycosis caused by Medicopsis romeroi in solid organ transplant recipients: Report of two cases and comprehensive review of the literature

Transpl Infect Dis. 2019 Jun;21(3):e13072. doi: 10.1111/tid.13072. Epub 2019 Mar 27.

Abstract

Medicopsis romeroi is a melanized coelomycetous fungus, mainly found in tropical and subtropical regions and an uncommon cause of infection in solid organ transplant (SOT) recipients. We describe two cases of SOT recipients diagnosed with phaeohyphomycosis due to M romeroi and provide a comprehensive literature review. These infections should be considered in patients native to tropical countries with a localized skin and soft tissue infection. Sequencing is needed for accurate identification of uncommon melanized fungi. Surgical treatment is recommended to cure the infection and co-adjunctive oral antifungals should be considered.

Keywords: dematiaceous fungi; melanized fungi; posaconazole; solid organ transplantation; voriconazole.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Ascomycota / drug effects
  • Ascomycota / pathogenicity*
  • Debridement
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Organ Transplantation / adverse effects*
  • Phaeohyphomycosis / diagnosis*
  • Phaeohyphomycosis / drug therapy
  • Retrospective Studies
  • Skin / microbiology*
  • Transplant Recipients
  • Tropical Climate

Substances

  • Antifungal Agents

Associated data

  • GENBANK/MK503139
  • GENBANK/MK503140