Chronic pain syndromes: overlapping phenotypes with common mechanisms

F1000Res. 2019 Mar 5:8:F1000 Faculty Rev-255. doi: 10.12688/f1000research.16814.1. eCollection 2019.

Abstract

The common chronic pain syndromes of fibromyalgia, regional pain syndrome, and complex regional pain syndrome have been made to appear separate because they have been historically described by different groups and with different criteria, but they are really phenotypically accented expressions of the same processes triggered by emotional distress and filtered or modified by genetics, psychology, and local physical factors.

Keywords: central sensitisation; complex regional pain syndrome; criteria; fibromyalgia; mechanisms; regional pain syndrome.

Publication types

  • Review

MeSH terms

  • Chronic Pain / diagnosis*
  • Chronic Pain / physiopathology*
  • Complex Regional Pain Syndromes / diagnosis
  • Complex Regional Pain Syndromes / physiopathology
  • Fibromyalgia / diagnosis
  • Fibromyalgia / physiopathology
  • Humans
  • Phenotype

Grants and funding

The author(s) declared that no grants were involved in supporting this work.