Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients

Immunotherapy. 2019 Apr;11(6):473-482. doi: 10.2217/imt-2018-0170.

Abstract

Aim: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients.

Methods: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement.

Results: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients.

Conclusion: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.

Keywords: allergies; cellular immunology; clinical immunology; immunological markers; immunotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Allergens / immunology
  • Antigens, Plant / immunology
  • B-Lymphocytes, Regulatory / immunology*
  • Basic-Leucine Zipper Transcription Factors / genetics
  • Basic-Leucine Zipper Transcription Factors / metabolism
  • Biomarkers / metabolism
  • Blood Circulation
  • Cryptomeria / immunology
  • Desensitization, Immunologic / methods*
  • Female
  • Humans
  • Injections, Subcutaneous
  • Interleukin-10 / genetics
  • Interleukin-10 / metabolism
  • Male
  • Middle Aged
  • Pollen / immunology
  • Rhinitis, Allergic, Seasonal / immunology
  • Rhinitis, Allergic, Seasonal / therapy*
  • T-Lymphocytes, Regulatory / immunology*
  • Young Adult

Substances

  • Allergens
  • Antigens, Plant
  • Basic-Leucine Zipper Transcription Factors
  • Biomarkers
  • NFIL3 protein, human
  • Interleukin-10