2-Phenylquinoline-Sugar Hybrids as Photoswitchable α-Glucosidase Inhibitors

Abstract

Purpose-designed 2-phenylquinoline (PQ)-sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an α-glucosidase target. The results indicated that PQ-mannose hybrid 2 selectively and effectively photodegraded α-glucosidase and significantly inhibited its enzymatic activity upon irradiation with long-wavelength UV light in the absence of any additives under neutral and aqueous conditions. Furthermore, 2 selectively and effectively inhibited α-glucosidase activity only with photo-irradiation even in complex cell lysate.

Keywords: 2-phenylquinoline; C-glycosides; hydrolases; photodegradation; α-glucosidase.