Granulomatous CNS inflammation associated with seminoma

Jennifer Massey; Susan Walker; Malcolm Galloway; Suran Fernando; John Parratt; Ann-Marie Quigley; Desmond P Kidd

doi:10.1007/s00415-019-09270-8

Granulomatous CNS inflammation associated with seminoma

J Neurol. 2019 Jun;266(6):1389-1393. doi: 10.1007/s00415-019-09270-8. Epub 2019 Mar 11.

Authors

Jennifer Massey¹, Susan Walker², Malcolm Galloway³, Suran Fernando⁴, John Parratt¹, Ann-Marie Quigley⁵, Desmond P Kidd⁶

Affiliations

¹ Department of Neurology, Royal North Shore Hospital, Sydney, Australia.
² Department of Neurology, Royal Free Hospital, London, UK.
³ Department of Cellular Pathology, Royal Free Hospital, London, UK.
⁴ Department of Immunology, Royal North Shore Hospital, Sydney, Australia.
⁵ Department of Nuclear Medicine, Royal Free Hospital, London, UK.
⁶ Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK. d.kidd@ucl.ac.uk.

PMID: 30859315
DOI: 10.1007/s00415-019-09270-8

Abstract

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment.

Keywords: Neurosarcoidosis; Sarcoidosis; Seminoma.

Publication types

Case Reports

MeSH terms

Adult
Central Nervous System Diseases / diagnosis
Central Nervous System Diseases / etiology*
Central Nervous System Diseases / pathology
Encephalitis / diagnosis
Encephalitis / etiology*
Encephalitis / pathology
Fatal Outcome
Humans
Lymphatic Diseases / diagnosis
Lymphatic Diseases / etiology*
Lymphatic Diseases / pathology
Male
Sarcoidosis / diagnosis
Sarcoidosis / etiology*
Sarcoidosis / pathology
Seminoma / complications*
Seminoma / diagnosis
Testicular Neoplasms / complications*
Testicular Neoplasms / diagnosis

Supplementary concepts

Neurosarcoidosis